The dataset contains fish mortality associated with various treatment of oil and dispersants in water accommodated fractions and sediment. The dataset also contains analytical chemistry associated with each experimental treatment. This dataset is associated with the following publications: Barron, M. Photoenhanced Toxicity of Petroleum to Aquatic Invertebrates and Fish. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. Springer, New York, NY, USA, 73(1): 40-46, (2017). Barron, M., J. Kryzwa, C. Lilavois, and S. Raimondo. Photoenhanced toxicity of weathered crude oil in sediment and water to larval zebrafish. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. Springer, New York, NY, USA, 100(1): 49-53, (2018).

The analysis of larval zebrafish locomotor behavior has emerged as a powerful indicator of perturbations in the nervous system and is used in many fields of research, including neuroscience, toxicology and drug discovery. The behavior of larval zebrafish however, is highly variable, resulting in the use of large numbers of animals and the inability to detect small effects. In this study, we analyzed whether individual locomotor behavior is stable over development and whether behavioral parameters correlate with physiological and morphological features, with the aim of better understanding the variability and predictability of larval locomotor behavior. Our results reveal that locomotor activity of an individual larva remains consistent throughout a given day and is predictable throughout larval development, especially during dark phases, under which larvae demonstrate light-searching behaviors and increased activity. The larvae’s response to startle-stimuli was found to be unpredictable, with no correlation found between response strength and locomotor activity. Furthermore, locomotor activity was not associated with physiological or morphological features of a larva (resting heart rate, body length, size of the swim bladder). Overall, our findings highlight the areas of intra-individual consistency, which could be used to improve the sensitivity of assays using zebrafish locomotor activity as an endpoint.

In zebrafish, 161 compounds were screened and 34 were identified by visual inspection as VDCs, of which 28 were confirmed as VDCs by quantitative image analysis. Testing of the zebrafish VDCs for their capacity to inhibit endothelial tube formation in the murine yolk-sac-derived endothelial cell line C166 identified 22 compounds that both disrupted zebrafish vascular development and murine endothelial in vitro tubulogenesis. This dataset is associated with the following publication: McCollum, C., J. Conde Vancells, C. Hans, M. Vazquez-Chantada, N. Kleinstreuer, T. Tal , T. Knudsen, S. Shah, F. Merchant, R. Finnell, J. Gustafsson, R. Cabrera, and M. Bondesson. (Reproductive Toxicology) Identification of vascular disruptor compounds by a tiered analysis in zebrafish embryos and mouse embryonic endothelial cells. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 70: 60-69, (2017).

This dataset includes data used to generate Figures 4C, 5B, 5C, and 5D in Tal et al. Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. Reproductive Toxicology. 2017. Data underlying all other figures shown in the manuscript are included in the Supplemental Tables published with the original article. This dataset is associated with the following publication: Tal , T., C. Kilty, A. Smith, C. LaLone , B. Kennedy, A. Tennant , C. McCollum, M. Bondesson, T. Knudsen , S. Padilla , and N. Kleinstreuer. Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 70: 70-81, (2017).

This dataset contains 60-min locomotor response data for all control, chemical and particulate-extract-treated zebrafish. This dataset is associated with the following publication: Stevens, J., S. Padilla, D. DeMarini, D. Hunter, K. Martin, L. Thompson, I. Gilmour, M. Hazari, and A. Farraj. Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 161(2): 290-299, (2018).