Gravity-driven membrane (GDM) filtration is a strategic alternative to conventional ultrafiltration (UF) for the resilient production of drinking water via ultrafiltration when resources become scarce, given the low dependency on energy and chemicals, and longer membrane lifetime. Implementation at large scale requires the use of compact and low costs membrane modules with high biopolymer removal capacity. We therefore evaluated (1) to what extent stable flux can be obtained with compact membrane modules, i.e., inside-out hollow fiber membranes, and frequent gravity-driven backwash, (2) if we can successfully utilize second-life UF modules to reduce membrane expenses, (3) if biopolymer removal could be maintained when applying a frequent backwash and with second-life modules and (4) which GDM filtration scenarios are economically viable compared to conventional UF, when considering the influence of new or second-life modules, membrane lifetime, stable flux value and energy pricing. Our findings showed that it was possible to maintain stable fluxes around 10 L/m2/h with both new and second-life modules for 142 days, but a daily gravity-driven backwash was necessary to compensate the continuous flux drop observed with compact modules. In addition, the backwash didn’t affect the biopolymer removal. Costs calculations revealed two significant findings: (1) using second-life modules made GDM filtration less expensive than conventional UF and (2) GDM filtration's overall costs were unaffected by energy prices rise, while conventional UF costs rose significantly, increasing the number of economically viable GDM filtration scenarios. In summary, we proposed an approach that could make GDM filtration in centralized facilities feasible.