This data set contains dose-response data for perchlorate exposure in multiple species. These data were assembled from peer-reviewed studies. Species included in this dataset are: rats (Rattus sp.), meadow voles (Microtus sp.), rabbits (Oryctolagus cuniculus), the African clawed frog (Xenopus laevis), zebrafish (Danio rerio), mosquito fish (Gambusia holbrooki), the bobwhite quail (Colinus virginianus), earthworms (Eisenia foetida), mosquito larvae (Culex quinquefasciatus), the water flea (Daphnia magna), and the sand dollar (Peronella japonica). This dataset is associated with the following publication: Hines, D., S. Edwards, R. Conolly, and A. Jarabek. The Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) frameworks facilitate the integration of human health and ecological endpoints for Cumulative Risk Assessment (CRA). ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(2): 839-849, (2018).