Input files for running the Community Multiscale Air Quality (CMAQ) modeling system. Input files include emissions, meteorology, boundary and initial conditions, and other ancillary data needed for running a simulation over the contiguous United States (12US2 domain) for December 22, 2015 - January 31, 2016. These input data can be used with two online tutorials described in Efstathiou et al. to set up and run a CMAQ simulation on Amazon Web Services and Microsoft Azure cloud computing resources. Data are netcdf formatted files using I/O API data structures (https://www.cmascenter.org/ioapi/). Information on variables within the files (variable names and units) and the model projection and grid structure is contained in the header information of each netcdf file.