This paper represents, to our knowledge, the first national-level (United States) estimate of the economic impacts of vibriosis cases as exacerbated by climate change. Vibriosis is an illness contracted through food- and waterborne exposures to various Vibrio species (e.g., non-V. cholerae O1 and O139 serotypes) found in estuarine and marine environments, including within aquatic life, such as shellfish and finfish. Data include all variables included in the regression models ("cleaned all"), climate variables ("cleaned climate vars"), county in which exposure occurred ("expcty"), county that reported diagnosis ("rptcty"), and sea surface temperature projections (identified by "SST"). Citation information for this dataset can be found in Data.gov's References section.