The dataset provided here documents the information used to generate figures for "The Role of Perfluorinated Acyl Fluoride Hydrolysis in Regional-Scale Model Predictions of Per- and Polyfluoralkyl Substance (PFAS) Chemistry, Transport, and Fate" published in ACS Environmental Science & Technology. This dataset is associated with the following publication: D'Ambro, E., B. Murphy, I. Piletic, J. Bash, and H. Pye. The Role of Perfluorinated Acyl Fluoride Hydrolysis in Regional-Scale Model Predictions of Per- and Polyfluoralkyl Substance (PFAS) Chemistry, Transport, and Fate. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 60(17): 13041–13050, (2026).