This dataset supports the journal article "Geographic Analysis of the Vulnerability of U.S. Lakes to Cyanobacterial Blooms under Future Climate", by Butcher et al. Two Excel spreadsheets containing the data presented/discussed in this paper will be uploaded to Science HUB. Data summaries include (1) a list of lakes included in the analysis (from 2007 National Lakes Assessment), including latitude/longitude coordinates, key lake physical attributes, and the set of vulnerability and risk metric developed and used in this analysis, and (2) a list of relevant articles identified in the literature and used to develop risk hypotheses used in this analysis. All Variable names and units are defined in column headings of each file uploaded to Science HUB. Details about the data and methodology used to develop risk metrics will be described in detail in a published journal article (draft paper will be submitted to the journal Earth Interactions, titled “Geographic Analysis of the Vulnerability of U.S. Lakes to Cyanobacterial Blooms under Future Climate”. This dataset is associated with the following publication: Butcher, J., M. Fernandez, T. Johnson, A. Shabani, and S. Lee. Geographic Analysis of the Vulnerability of U.S. Lakes to Cyanobacterial Blooms under Future Climate. Earth Interactions. American Meteorological Society, Boston, MA, USA, 27(1): e230004, (2023).