The dataset description is within each data spreadsheet included in this record (first tab of each). This dataset is associated with the following publication: Lambert, F., D. Vivian, S. Raimondo, C. Stevens, and M. Barron. Relationships between aquatic toxicity, chemical hydrophobicity, and mode of action: log Kow revisited. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. Springer, New York, NY, USA, 83(4): 326-338, (2022).