After a wide-area biological contamination incident populations residing within minimally contaminated areas may be instructed to shelter-in-place and need to perform infection control within their homes. Previous research within HSMMD has found hot water laundering effective for the decontamination of Phi6 bacteriophage and hot water laundering + bleach effective for the decontamination of the B. anthracis surrogate Bg. This dataset expands upon previous work to include six different laundering methods, some including sanitizers, and four different microorganisms (Phi6, MS2, Klebsiella pneumoniae, and Staphylococcus aureus). The dataset includes eight different textiles.