Passive and active VOC measurements were collected weekly for 15 months between December 2020 and April 2022 at the Fairbanks, AZ site. Various indicators and tracers (I&T), including indoor radon, differential pressure, temperature, and other environmental factors, were also collected. Results from this study help clarify the factors that influence temporal trends in VOC concentrations across multiple sampling zones in commercial buildings in a subarctic climate zone and thus inform vapor intrusion sampling strategies. This dataset is associated with the following publication: Zimmerman, J., A. Williams, B. Schumacher, C. Lutes, R. Warrier, B. Cosky, B. Thompson, C. Holton, and K. Bronstein. Impact of Multiple HVAC Systems on Indoor Air VOC and Radon Concentrations from Vapor Intrusion During Seasonal Usage. ATMOSPHERE. MDPI, Basel, SWITZERLAND, 16(4): 378, (2025).