It contains the raw values for endpoints for individual animals within treatment groups that are reported in tables and figures. This dataset is associated with the following publication: Lewis, A., A. Biales, C. Miller, W. Oshiro, T. Beasley, M. Schladweiler, G. Momplaisir, B. Flick, M.J. See, R. Huang, W. Williams, M. Moore, G. Casuccio, L. Li, M. Deible, R. Grindstaff, T. Jackson, M. Hazari, K. Rogers, K. Ho, and A. Farraj. A Single Oral Exposure to Polyethylene Terephthalate Microplastics Causes Mild Metabolic and Gastrointestinal Disruption: Dose and Sex as Effect Modifiers. DRUG AND CHEMICAL TOXICOLOGY. Marcel Dekker Incorporated, New York, NY, USA, 1-18, (2026).