Wipe sampling variables (such as wipe wetting solvent, pesticide concentration effects, commercial products, number of wipes per tested surface) were evaluated to determine their potential effects on method performance and how they may alter surface recoveries. This dataset is associated with the following publication: Willison, S., D. Stout, A. Mysz, J. Starr, D. Tabor, B. Wyrzykowska-Ceradini, J. Nardin, E. Morris, and E. Snyder. The impact of wipe sampling variables on method performance associate with indoor pesticide misuse and highly contaminated areas. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 655: 539-546, (2019).