This data is stream flow and nutrient data (dissolved inorganic nitrogen and total phosphorus) for 6 sites in the Shepherd Creek watershed, Cincinnati, OH. The data could be useful to others with interest in studying nutrient loading in small streams draining suburban hillslopes. This dataset is associated with the following publication: Riasi, S., A. Teklitz, W. Shuster, C. Nietch, and L. Yeghiazarian. Reliability-Based Water Quality Assessment with Load Resistance Factor Design: Application to TMDL. Journal of Hydrologic Engineering. American Society of Civil Engineers (ASCE), Reston, VA, USA, 23(12): 1943-5584, (2018).