The dataset contains chromatographic retention times, CAS numbers and name of chemical compounds identified/tentatively identified in pyrolysates of tire road wear samples. Also attached are pyrolysis-GC-MS chromatograms or pyrograms obtained for the samples. This dataset is associated with the following publication: Paterson, K., B. Beckingham, G. Momplaisir, and K. Varner. Adapting Methods for Isolation and Enumeration of Microplastics to Quantify Tire Road Wear Particles with Confirmation by Pyrolysis GC–MS. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 1769–1779, (2025).