This dataset contains raw experimental data from microfluidics-based injectivity and reversibility tests of ionic liquids (ILs) and alternative fluids (AFs). Fluids were injected through individual and combined microchannels at three temperatures (18 C, 50 C, and 80 C), and differential pressure was recorded across varying flow rates. Voltage data were acquired using a DAQ system and converted to pressure using calibrated equations. The injectivity dataset includes differential pressure versus flow rate measurements for multiple ILs, diluted IL solutions, and reference fluids (DI water, WBF-2, OBF-1), organized by fluid type, concentration, microchannel configuration, and test temperature. The reversibility dataset records time-dependent pressure differential for water-IL/AF-water flow sequences. Additional sheets include pressure sensor calibration curves, fluid property measurements (viscosity, density), and channel dimensional data.