The data resource consists of invasive tree species individual responses to mechanical-chemical/chemical treatments on plots established on invaded sub-tropical mountain secondary forests (Yungas). Those plots are in the Horco Molle experimental reserve and Parque Sierra de San Javier (Horco Molle), Tucumán, Argentina. The current database belongs to an experiment that we conducted to investigate management control of the invasion of non-native species Ligustrum and other exotic species to restore native tree diversity from June 2020 to November 2023. The work was carried out as part of NERC grant NE/S011641/1 Optimising the long-term management of invasive species affecting biodiversity and the rural economy using adaptive management.