The supplemental information for this paper includes chemical-specific analytical methods, raw instrument data for chemical concentration analysis, processed data for experiments on intrinsic hepatic clearance (CLint -- metabolism) and chemical fraction unbound in the presence of human plasma protein (fup). Figures showing the curve fits for determining CLint are provided. Finally, all data were released publicly as HTTK R Package v1.10.1. This dataset is associated with the following publication: Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, and R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2): 235-251, (2019).