This is the complete dataset of the study MF_21_1, which investigates the impact of high living temperatures and housing on cardiopulmonary and behavioral function in mice and subsequent response to eucalyptus wildfire smoke. This dataset is associated with the following publication: Fiamingo, M., T. Jackson, S. Toler, W. Oshiro, K. McDaniel, L. Klein, K. Lee, P. Evansky, I. Gilmour, A. Farraj, and M. Hazari. The Impacts of Housing Conditions on the Cardiopulmonary and Neurobehavioral Responses of Mice to High Temperature and Wildfire Smoke. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 59(22): 10929-10943, (2025).