This dataset supports the manuscript "Relationship between temperature and mortality in the United States: changes in city level vulnerability and implications for future projections based on a geographically clustered meta-regression", in press at Lancet Planetary Health. The dataset includes a description of primary data sources, the code used to process the primary data, the intermediate data produced, and the code used to produce figures for the paper. Citation information for this dataset can be found in the EDG's Metadata Reference Information section and Data.gov's References section.