The file "Read-ME data & P-graph instructions 03-12-24 .docx" describes the step-by-step process to collect Information (for new models), prepare functional units/operations (for new models), modify existing model, use the P-Graph software, verify process units and flow values, extract supply chain structural solutions, and perform cost assessments to each structural solution. The file "File_plastics_2901_JP.zip" contains the P-Graph software file "File_plastics_2901_JP.pgsx" to generate all feasible plastic end-of-life supply chain structural solutions for the case study as shown in Figure 6. Figure 7 depicts selected cost-effective pathways derived from the P-graph model with the (a) lowest (647,303 EUR/y) and (b) highest (698,440 EUR/y) annualized costs. The file "Cost Calculation- Operational Capacity -1801.xlsx" has all cost parameters, equipment specifications, and location information needed to run the P-Graph plastic end-of-life supply chain case study. The file "Figure 8 - Datapoints_results_of_File_plastics_2901_JP_pgsx.xlsx" contains all total recycling costs for the most cost-effective 100 solutions generated by the P-graph model shown in Figure 8. Figures 1 and 5 can be obtained from the cited public domain repositories. This dataset is associated with the following publication: Kumar, B., J. Pimentel, N.A. Cano-Londono, G.J. Ruiz-Mercado, C.T. Deak, and H. Cabezas. Designing cost-effective supply chains for plastics at the end-of-life. JOURNAL OF CLEANER PRODUCTION. Elsevier Science Ltd, New York, NY, USA, 501: 145227, (2025).