The objective of this research was to predict nutrient, chlorophyll-a, and associated harmful algal bloom, hypoxia, and eutrophication effects in US lakes. This research used nutrient and chlorophyll-a concentration data from the National Lakes Assessment (NLA), soil, landcover, and landscape characteristic data from LakeCat, landscape nutrient data from the National Nutrient Inventory (NNI), nutrient deposition data from the National Atmospheric Deposition Program (NADP), climate data from PRISM, landscape ecosystem data from the Earth Observatory Network (EON), and lake depth data from LAGOS and the National Hydrography Dataset (NHD). Prediction data of total nitrogen, total phosphorus, and chlorophyll-a concentrations were summarized at the catchment and lake watershed scales.