Supplementary information for "Examining environmental matrix effects on quantitative non-targeted analysis estimates of per- and polyfluoroalkyl substances". This dataset is associated with the following publication: Pu, S., J. McCord, R. Dickman, N. Sayre-Smith, H. Sepman, A. Kruve, D. Aga, and J. Sobus. Examining environmental matrix effects on quantitative non-targeted analysis estimates of per- and polyfluoroalkyl substances. Analytical and Bioanalytical Chemistry. Springer, New York, NY, USA, 417(10): 2097-2110, (2025).