This research effort represents our initial method development research for soil gas, sewer gas, and indoor air samples for PFAS analyses as related to vapor intrusion. The product and associated subsequent products will be consistently updated leading to a constantly expanding database incorporating additional experiments. This dataset is associated with the following publication: Hayes, H., C. Lutes, N. Watson, D. Benton, D. Hanigan, S. McCoy, C. Holton, K. Bronstein, B. Schumacher, J. Zimmerman, and A. Williams. Laboratory development and validation of vapor phase PFAS methods for soil gas, sewer gas, and indoor air. Environmental Science: Atmospheres. Royal Society of Chemistry, Cambridge, UK, 5: 94-109, (2025).