This dataset contains 2015 national-level water withdrawal by North American Industry Classification System (NAICS) 2012 6-digit codes. This dataset was generated with FLOWSAv1.0.0 by calling the getFlowBySector() function and passing "Water_national_2015_m1" as the method name. FLOWSA is a publicly available python package that generates standardized environmental flows by industry (https://github.com/USEPA/flowsa/releases/tag/v1.0.0). The metadata text file included as a supporting document records the FLOWSA tool version and input dataset bibliographic details. This dataset is associated with the following publication: Ingwersen, W.W., M. Li, B. Young, J. Vendries, and C. Birney. USEEIO v2.0, The US Environmentally-Extended InputOutput Model v2.0. Scientific Data. Springer Nature Group, New York, NY, 194, (2022).