This data set is broken up into 2 Excel files. In one file are all the data pertaining to the vascular and pulmonary effects of ozone exposure in rats fed either a normal diet or diet enriched with coconut oil, fish oil, or olive oil. The different tabs of the spreadsheet pertain to each figure or table found in the manuscript. This file was updated on 12/7/17 to reflect changes to Figure 3 in response to reviewers comments following submission to Toxicological Sciences. In the second file is all the data for Figure 8 pertaining to the global microRNA assessment. This dataset is associated with the following publication: Snow, S., W. Cheng, A. Henriquez, M. Hodge, V. Bass, G. Nelson, G. Carswell, J. Richards, M. Schladweiler, A. Ledbetter, B. Chorley, K. Gowdy, H. Tong, and U. Kodavanti. Ozone-Induced Vascular Contractility and Pulmonary Injury are Differentially Impacted by Diets Enriched with Coconut Oil, Fish Oil, and Olive Oil. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1): 57-69, (2018).