Dataset for manuscript titled, "Ozone responsive gene expression as a model for describing repeat exposure response trajectories and inter-individual toxicodynamic variability in vitro" published in Toxicological Sciences (2022), 185(1): 38-49. Metadata are in the Readme tab within the data file. This dataset is associated with the following publication: Bowers, E., E. Martin, A. Jarabek, D. Morgan, H. Smith, L. Dailey, E. Aungst, D. Diaz-Sanchez, and S. McCullough. Ozone responsive gene expression as a model for describing repeat exposure response trajectories and interindividual toxicodynamic variability in vitro. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 185(1): 38-49, (2022).