Data provided here include WASP input files and simulation outputs (Dissolved Oxygen (mg/l) and Phytoplankton (ug chl a/L). Simulation Outputs for base case year as well as scenario testing for changes in nutrient loads. Observed Data are also provided for sites of interest including sonde (15 min) and grab samples (depth profile). This dataset is associated with the following publication: Knightes, C. Simulating Hypoxia in a New England Estuary: WASP8 Advanced Eutrophication Module (Narragansett Bay, RI, USA). WATER. MDPI, Basel, SWITZERLAND, 15(6): 1204, (2023).