Data and supplemental figures for manuscript titled "Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs." We used a catheterized conscious pig model to estimate inter-organ flux of xenometabolites, derivatives, and bile acids using LC/MS. Female pigs (n=12; 2-3 months old; 25.6 ± 2.2 kg) had surgically-implanted catheters across portal-drained viscera (PDV), splanchnic area (SPL), liver, kidney, and hindquarter muscle. Overnight fasted arterial and venous plasma was collected simultaneously in a conscious state and stored at -80°C. Thawed samples were analyzed by liquid chromatography-mass spectrometry. Plasma flow was determined with para-aminohippuric acid dilution technology and used to calculate net organ balance for each metabolite. This repository contains the LC/MS data and supplemental figures for the submitted manuscript.
OwnerUnited States Department of Agriculture - view all
Update frequencyunknown
Last updated10 months ago
OverviewNP107inter organ balancemetabolomicspig modeltissue fluxxenometabolite
Additional Information
KeyValue
dcat_modified2022-09-28
dcat_publisher_nameAgricultural Research Service
guida2950fe2-e4db-4151-b39a-c490943d17ed
language
harvest_object_id23835f3f-66fe-4fdd-8d91-077ce8c4f874
harvest_source_id2c0b1e04-ba48-4488-9de5-0dab41f9913f
harvest_source_titleUSDA Open Data Catalog