This dataset contains thermohydraulic measurements of fluid flow through single and dual fracture systems under controlled laboratory conditions. Experiments were conducted at Oklahoma State University using various ionic and nonionic fluids, including deep eutectic solvents (DES), 1-hexylpyridinium bromide ([HPy][Br]), water-based fluids, oil-based fluids, and water, at multiple concentrations and operational conditions. The objective was to characterize fluid behavior across a range of flow rates, temperatures, and fracture configurations relevant to geothermal reservoir conditions. The dataset includes raw time-series data collected at 1 Hz sampling frequency. Measurements were performed under multiple flow regimes (1 to 4 GPM) and thermal conditions (room temperature to 230 F).