This data has been used to quantify phosphorus, nitrogen, total solids, and water flows in 101'548 sanitation systems generated from 41 potential technologies appropriate for a small town (Katarnyia) in Nepal. The data contains input and output data for a didactic case as well as the full application to Katarniya. The input data is a csv file with the compiled information on the 41 technologies collected from literature on the technologies. This includes the technology appropriateness profiles and scores and in particular the transfer coefficients of the four substances in question. Results include: (1) all valid sanitation system configurations; (2) a a smaller set of divers and highly appropriate sanitation system options as an input into decision-making; (3) substance flows for phosphorus, nitrogen, total solids, and water and recovery and loss potential.