The CCS (Carbon Capture and Storage) Pipeline Route Planning Database (v1.0) is a geospatial resource, containing over 90 gigabytes of data representing critical considerations for the spatial routing of pipelines and transport of CO2, from source to sink. Considerations include state-specific regulations and restrictions, energy and social justice factors, land use requirements, existing infrastructure, and areas of potential risk. Built to support smart and safe route planning strategies for CO2 transport, the more than 40 layers of this database have been weighted (Weight fields) according to current federal and state-level regulations and pipeline construction recommendations. Weighted values range from zero to one, where zero represents acceptable areas for pipeline placement and CO2 transport areas based on the various considerations, and a value of one represents areas that should be avoided. This database will be a key input for the upcoming CCS Pipeline Route Planning Tool, which is currently in alpha testing.